Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20373742 | 0.80 | MAPK1 (0.43) | LMNAALDH1A1KDM4EMAPK1BRD4 | |
| SCHEMBL18326368 | 0.80 | HTT (0.48) | LMNAKDM4EMAPK1BRD4CREBBP | |
| SCHEMBL20373357 | 0.80 | NOX4 (0.43) | MAOBALDH1A1KDM4EBRD4CNR2 | |
| SCHEMBL20373789 | 0.74 | PDE10A (0.41) | KMT2A | |
| SCHEMBL20373766 | 0.72 | GPR84 (0.36) | — | |
| SCHEMBL16905795 | 0.72 | CREBBP (0.51) | BRD4CREBBP | |
| SCHEMBL20373746 | 0.69 | AKR1C3 (0.43) | LMNAKDM4EKMT2A | |
| SCHEMBL20373739 | 0.68 | SCN7A (0.41) | ALDH1A1KDM4ESCN7ASCN5ASCN2A | |
| SCHEMBL20373756 | 0.67 | BRD4 (0.36) | MAOBALDH1A1KDM4EBRD4CREBBP | |
| SCHEMBL28901289 | 0.65 | SCN7A (0.48) | LMNAALDH1A1BRD4CREBBPCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |