Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18326374 | 0.80 | HTR2A (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL9959670 | 0.75 | HDAC1 (0.45) | MAPTCCR2HDAC1HDAC6KDM4E | |
| SCHEMBL20373741 | 0.75 | LMNA (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL16544446 | 0.73 | CYP19A1 (0.37) | ALDH1A1CCR2TP53MCL1 | |
| SCHEMBL16896795 | 0.67 | HTR2A (0.41) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL31202639 | 0.67 | BRPF1 (0.65) | MEN1KMT2AALDH1A1CCR2BRD4 | |
| SCHEMBL22632582 | 0.66 | NPC1 (0.46) | NPC1ALDH1A1MAPTSMN1; SMN2NPSR1 | |
| SCHEMBL13696064 | 0.65 | HTR6 (0.67) | HDAC1HDAC6DNM1 | |
| SCHEMBL16029732 | 0.63 | TSHR (0.77) | ALDH1A1MAPTSMN1; SMN2NPSR1TP53 | |
| SCHEMBL6086626 | 0.63 | HDAC8 (0.55) | KMT2AHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |