Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18326375 | 0.81 | SCN9A (0.46) | SCN9AKMT2AMEN1ALDH1A1PKM | |
| SCHEMBL20373765 | 0.79 | BRD4 (0.45) | SCN9ASYKAURKBINCENPKMT2A | |
| SCHEMBL20373577 | 0.76 | SCN9A (0.41) | SCN9AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL16896733 | 0.74 | BRD4 (0.53) | SCN9A | |
| SCHEMBL20373279 | 0.72 | PDE1A (0.40) | SYKAURKBINCENPKMT2AMEN1 | |
| SCHEMBL20373356 | 0.71 | PLA2G2A (0.39) | SYKAURKBINCENPKMT2AMEN1 | |
| SCHEMBL20373579 | 0.70 | AR (0.37) | SYKAURKBINCENPKMT2AMEN1 | |
| SCHEMBL20373585 | 0.67 | POLB (0.38) | KMT2AMEN1ALDH1A1KDM4EPOLB | |
| SCHEMBL18326377 | 0.66 | SCN9A (0.47) | SCN9ASYKKMT2AMEN1ALDH1A1 | |
| SCHEMBL18359530 | 0.66 | PDE1A (0.37) | SYKAURKBINCENPKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | disclosed |