Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 4/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802140 | 0.87 | HTR3A (0.53) | PARP1HRH4KDM4EALDH1A1 | |
| SCHEMBL20377819 | 0.71 | HRH4 (0.46) | SMPD3HRH4CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL12166977 | 0.70 | SMPD3 (0.44) | SMPD3PARP1GRM2HRH4CRHBP | |
| SCHEMBL29967049 | 0.69 | TERT (0.51) | HRH4SMN1; SMN2KDM4EGAAL3MBTL1 | |
| SCHEMBL7914443 | 0.69 | RAB9A (0.41) | SMN1; SMN2KDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL20015997 | 0.68 | SMPD3 (0.68) | SMPD3 | |
| SCHEMBL23346697 | 0.67 | PI4KA (0.40) | ALDH1A1MAPK1PIM1 | |
| SCHEMBL15525119 | 0.67 | PDE2A (0.40) | KDM4EGAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL25382823 | 0.67 | NOTUM (0.39) | GAAMAPK1HTR2C | |
| SCHEMBL30503614 | 0.67 | MAPT (0.37) | KDM4EL3MBTL1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180201609-A1 | INDAZOLE AND AZAINDAZOLE COMPOUNDS AS IRAK-4 INHIBITORS | IRAK4, IRAK3, IRAK2 | SMPD3 3651/4885PARP1 952/4885GRM2 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.