Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | PPM1D | O15297 | 3/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 3/20 | 0.45 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400984 | 0.86 | S1PR1 (0.49) | KDM4CPPM1DHAO1KMOSERPINE1 | |
| SCHEMBL20401001 | 0.86 | SERPINE1 (0.51) | KDM4CPPM1DHAO1KMOSERPINE1 | |
| SCHEMBL20401410 | 0.85 | STAT3 (0.46) | KDM4CHAO1KMOSTAT3SSTR3 | |
| SCHEMBL20401023 | 0.84 | ALOX15 (0.53) | KDM4CPPM1DSTAT3MEN1ALDH1A1 | |
| SCHEMBL2647028 | 0.80 | HAO1 (0.52) | KDM4CHAO1KMOSERPINE1MEN1 | |
| SCHEMBL1711030 | 0.79 | HDAC8 (0.59) | KDM4CMEN1ALDH1A1POLBKMT2A | |
| SCHEMBL20401097 | 0.78 | PTGFR (0.53) | KDM4CMEN1ALDH1A1POLBKMT2A | |
| SCHEMBL11511834 | 0.77 | USP1 (0.48) | KDM4CKMT2AHTR2CHTR2BHDAC1 | |
| SCHEMBL20401012 | 0.76 | S1PR1 (0.46) | KDM4CHAO1KMOSTAT3MEN1 | |
| SCHEMBL32660010 | 0.75 | ALOX15 (0.61) | PPM1DSSTR3ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136935-A1 | 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS | UNIVERSITY OF HAWAII (US) | 2018-07-26 | — | — | WO | disclosed |