Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | PPM1D | O15297 | 3/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400797 | 0.86 | KDM4C (0.50) | PPM1DKDM4CHAO1KMOSERPINE1 | |
| SCHEMBL20401001 | 0.86 | SERPINE1 (0.51) | PPM1DKDM4CHAO1ALOX15KMO | |
| SCHEMBL20401012 | 0.85 | S1PR1 (0.46) | S1PR1KDM4CHAO1KMOSTAT3 | |
| SCHEMBL29447550 | 0.84 | ALOX15 (0.58) | PPM1DALOX15STAT3ALDH1A1NPC1 | |
| SCHEMBL20418537 | 0.84 | ALOX15 (0.58) | PPM1DALOX15STAT3ALDH1A1NPC1 | |
| SCHEMBL22453743 | 0.81 | S1PR1 (0.55) | S1PR1HAO1KMOSERPINE1KMT2A | |
| SCHEMBL2647028 | 0.80 | HAO1 (0.52) | KDM4CHAO1KMOSERPINE1KMT2A | |
| SCHEMBL31003876 | 0.78 | KMO (0.50) | S1PR1HAO1KMOSERPINE1KMT2A | |
| SCHEMBL20401410 | 0.76 | STAT3 (0.46) | KDM4CHAO1KMOSTAT3KMT2A | |
| SCHEMBL15215022 | 0.74 | KDR (0.47) | KDM4CHAO1ALDH1A1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136935-A1 | 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS | UNIVERSITY OF HAWAII (US) | 2018-07-26 | — | — | WO | disclosed |