Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.46 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400797 | 0.85 | KDM4C (0.50) | STAT3HAO1KMOHTR2CHTR2B | |
| SCHEMBL20401012 | 0.85 | S1PR1 (0.46) | STAT3HAO1KMOHTR2CHTR2B | |
| SCHEMBL20401408 | 0.84 | STAT3 (0.49) | STAT3MEN1ALDH1A1KMT2A | |
| SCHEMBL2647028 | 0.79 | HAO1 (0.52) | HAO1KMOHTR2CHTR2BKDM4C | |
| SCHEMBL20400984 | 0.76 | S1PR1 (0.49) | STAT3HAO1KMOHTR2CHTR2B | |
| SCHEMBL20401001 | 0.76 | SERPINE1 (0.51) | STAT3HAO1KMOHTR2CHTR2B | |
| SCHEMBL2377234 | 0.74 | VNN1 (0.55) | ALDH1A1POLBPPARAVNN1 | |
| SCHEMBL20401023 | 0.73 | ALOX15 (0.53) | STAT3KDM4CMEN1ALDH1A1KMT2A | |
| SCHEMBL17084777 | 0.72 | ACMSD (0.52) | STAT3HTR2CHTR2BKDM4CPPARA | |
| SCHEMBL354930 | 0.71 | KMO (0.62) | HAO1KMOMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136935-A1 | 2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS | UNIVERSITY OF HAWAII (US) | 2018-07-26 | — | — | WO | disclosed |