Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18661502 | 0.89 | PDE10A (0.39) | KMT2AMEN1RORCGPBAR1PDE10A | |
| SCHEMBL20394297 | 0.86 | ABL1 (0.41) | KMT2AMEN1GPBAR1PDE10A | |
| SCHEMBL20394448 | 0.85 | PDE10A (0.45) | PDE10AL3MBTL1MAPTNPSR1 | |
| SCHEMBL20406442 | 0.84 | RORC (0.32) | KMT2AMEN1RORCP2RY1GPBAR1 | |
| SCHEMBL20406391 | 0.82 | MEN1 (0.46) | KMT2AMEN1P2RY1PDE10A | |
| SCHEMBL20406479 | 0.81 | MEN1 (0.35) | KMT2AMEN1P2RY1 | |
| SCHEMBL20406690 | 0.80 | PDE10A (0.38) | KMT2AMEN1RORCPDE10A | |
| SCHEMBL20394306 | 0.79 | FEN1 (0.35) | GPBAR1PDE10AMAPTNPSR1 | |
| SCHEMBL20394474 | 0.79 | SYK (0.41) | GPBAR1PDE10AMAPTNPSR1 | |
| SCHEMBL20406169 | 0.78 | PDE10A (0.39) | KMT2AMEN1PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351533-A1 | BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 2018-07-25 | — | — | EP | disclosed |