Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984310 | 0.79 | CYP11B1 (0.51) | TLR8ICMTIDO1CYP11B1CYP11B2 | |
| SCHEMBL10983627 | 0.78 | IDO1 (0.44) | ADORA2AIDO1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL15653534 | 0.78 | CYP11B1 (0.54) | TLR8IDO1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL593796 | 0.77 | CYP11B1 (0.58) | TLR8HPGDSIDO1CYP11B1CYP11B2 | |
| SCHEMBL4022684 | 0.77 | HPGDS (0.54) | HPGDSPIK3CDIDO1GAAALDH1A1 | |
| SCHEMBL27490347 | 0.77 | TLR8 (0.51) | TLR8ICMTIDO1CYP11B1CYP11B2 | |
| SCHEMBL10981864 | 0.75 | CYP11B1 (0.57) | TLR8CYP11B1CYP11B2 | |
| SCHEMBL21820757 | 0.72 | CYP11B1 (0.50) | TLR8ICMTIDO1CYP11B1CYP11B2 | |
| SCHEMBL1502180 | 0.70 | IDO1 (0.49) | ICMTIDO1CYP11B1CYP11B2FYN | |
| SCHEMBL30669816 | 0.70 | P2RX3 (0.49) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018136202-A2 | COMPOUNDS AND METHODS FOR CDK8 MODULATION AND INDICATIONS THEREFOR | PLEXXIKON INC. (US) | 2018-07-26 | — | — | WO | disclosed |