Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20418831 | 0.86 | MAPT (0.56) | MAPTCYP3A4CYP2D6CYP1A2MAPK1 | |
| SCHEMBL8971670 | 0.73 | ALDH1A1 (0.44) | MAPTCYP1A2CYP2C19FDPSALDH1A1 | |
| Hydrochloric Acid SCHEMBL8971417 | 0.72 | ALDH1A1 (0.43) | MAPTCYP1A2CYP2C19FDPSALDH1A1 | |
| SCHEMBL15979037 | 0.70 | MAPT (0.51) | MAPTCYP3A4CYP2D6CYP1A2MAPK1 | |
| SCHEMBL12565433 | 0.70 | MAPT (0.51) | MAPTCYP3A4CYP2D6CYP1A2MAPK1 | |
| SCHEMBL18057578 | 0.69 | NPSR1 (0.42) | MAPTCYP3A4CYP2D6CYP1A2MAPK1 | |
| SCHEMBL7602247 | 0.69 | CYP1A2 (0.62) | MAPTCYP1A2MAPK1CYP2C19NPSR1 | |
| SCHEMBL12786929 | 0.69 | DHODH (0.72) | MAPTCYP1A2CYP2C19NPSR1ALDH1A1 | |
| SCHEMBL6730848 | 0.69 | CYP1A2 (0.62) | MAPTCYP1A2MAPK1CYP2C19NPSR1 | |
| SCHEMBL368253 | 0.68 | LPO (0.39) | MAPTCYP1A2MAPK1ALDH1A1RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | Sanford Burnham Prebys Medical Discovery Institute | 2018-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180207140-A1 | Pyrazolopyrimidines as Inhibitors of Glucocorticoid Receptor Translocation | NR3C1, NR3C2, GRK3 | MAPT 1843/4885CYP3A4 2711/4885CYP2D6 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.