SCHEMBL368253

SCHEMBL368253

CCOC(=O)C(=O)c1nccn1C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPO P22079 2/20 0.39
LMNA P02545 1/20 0.39
CYP1A2 P05177 1/20 0.39
ALDH1A1 P00352 5/20 0.39
RGS12 O14924 1/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
HTT P42858 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
NAMPT P43490 1/20 0.38
ATM Q13315 1/20 0.38
JMJD6 Q6NYC1 1/20 0.37
RAB9A P51151 3/20 0.36
NPC1 O15118 2/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LDHA P00338 1/20 0.36
LDHB P07195 1/20 0.36
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1822302 0.83 ALDH1A1 (0.46) LPOLMNACYP1A2ALDH1A1RGS12
SCHEMBL25254399 0.81 ALDH1A1 (0.39) LPOLMNACYP1A2ALDH1A1RGS12
SCHEMBL402733 0.78 MGAM (0.42) LPOLMNACYP1A2ALDH1A1RGS12
SCHEMBL18366656 0.76 TNF (0.40) ALDH1A1RGS12MAPTPOLB
SCHEMBL368414 0.74 NAMPT (0.44) LPOLMNAALDH1A1MAPTHTT
SCHEMBL20267842 0.73 JMJD6 (0.47) LMNAALDH1A1RGS12MAPTHTT
1-Methylimidazole SCHEMBL8045723 0.73 TBXAS1 (0.45) CYP1A2ALDH1A1RGS12MAPTNAMPT
SCHEMBL12094827 0.73 NAMPT (0.43) LPOLMNAALDH1A1MAPTHTT
SCHEMBL29441633 0.72 ALDH1A1 (0.41) CYP1A2ALDH1A1RGS12MAPTJMJD6
SCHEMBL5604635 0.72 TSHR (0.49) LPOLMNAALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624010-B2 Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway AC IMMUNE SA (CH) 2026-05-12 US disclosed
EP-4168395-B1 DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY AC IMMUNE SA (CH) 2026-03-25 EP disclosed
US-20230250070-A1 DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY AC IMMUNE SA (CH) 2023-08-10 US disclosed
US-20230250070-A1 DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY AC IMMUNE SA (CH) 2023-08-10 US disclosed
EP-4168395-A1 DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY AC Immune SA (CH) 2023-04-26 EP disclosed
CN-115768754-A Dihydrooxazole and thiourea or urea derivatives that modulate NLRP3 inflammasome pathways AC免疫有限公司 2023-03-07 CN disclosed
WO-2021255279-A1 D I H YD ROOXAZO LE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY AC IMMUNE SA (CH) 2021-12-23 WO disclosed
EP-2593425-B1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE AGIOS PHARMACEUTICALS INC (US) 2018-10-17 EP disclosed
US-20160264621-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2016-09-15 US disclosed
US-20160264621-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2016-09-15 US disclosed
US-20160264621-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2016-09-15 US disclosed
US-20130184222-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2013-07-18 US disclosed
US-20130184222-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2013-07-18 US disclosed
US-20130184222-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE AGIOS PHARMACEUTICALS, INC (US) 2013-07-18 US disclosed
EP-2593425-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE Agios Pharmaceuticals, Inc. (US) 2013-05-22 EP disclosed
WO-2012009678-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHOD OF USE AGIOS PHARMACEUTICALS, INC. (US) 2012-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624010-B2 Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway NOD1, NLRP3, NLRP1 LPO 2738/4885LMNA 2131/4885CYP1A2 550/4885
US-20130184222-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE IDH1, IDH3B, IDH3A LPO 4637/4885LMNA 2076/4885CYP1A2 2921/4885
US-20230250070-A1 DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY NLRP3, NOD1, NLRP1 LPO 3599/4885LMNA 4053/4885CYP1A2 954/4885
US-20160264621-A1 THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE IDH1, IDH3B, IDH3A LPO 4637/4885LMNA 2076/4885CYP1A2 2921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.