Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20415341 | 0.87 | OPRK1 (0.48) | SMN1; SMN2DRD4ALDH1A1TDP1OPRK1 | |
| SCHEMBL20415259 | 0.77 | OPRK1 (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL20415346 | 0.76 | NTSR1 (0.45) | ALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL20415250 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TDP1KMT2AOPRK1 | |
| SCHEMBL20415216 | 0.71 | OPRK1 (0.56) | DRD2SMN1; SMN2DRD4DRD3SIGMAR1 | |
| SCHEMBL10078311 | 0.67 | KMO (0.67) | DRD2DRD3SIGMAR1MEN1KMT2A | |
| SCHEMBL20415165 | 0.67 | HPGD (0.53) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL27674481 | 0.67 | KMO (0.58) | DRD2DRD4DRD3SIGMAR1ALDH1A1 | |
| SCHEMBL29073232 | 0.66 | CES2 (0.55) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL11099529 | 0.65 | CA12 (0.48) | SMN1; SMN2ALDH1A1TDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397652-A2 | 3-(PHENYL)-2-(AMINOMETHYL)-1-PHENYL-2-PROPEN-1-ONE DERIVATIVES AS INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR FOR TREATING PROSTATE CANCER | The Regents of the University of California (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2018136792-A1 | INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-07-26 | — | — | WO | disclosed |