Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19690771 | 0.76 | — | — | |
| SCHEMBL1522730 | 0.74 | — | — | |
| SCHEMBL19354579 | 0.74 | — | — | |
| SCHEMBL6920447 | 0.74 | KDM4E (0.37) | KDM4ETSHRHTTMAPTSMN1; SMN2 | |
| SCHEMBL454997 | 0.71 | MAPT (0.43) | KDM4ETSHRHTTMAPTSMN1; SMN2 | |
| SCHEMBL2044222 | 0.71 | SMN1; SMN2 (0.43) | KDM4ETSHRHTTMAPTSMN1; SMN2 | |
| SCHEMBL9522063 | 0.71 | AKT1 (0.43) | KDM4ETSHRHTTMAPTSMN1; SMN2 | |
| SCHEMBL11279009 | 0.70 | MAPK1 (0.39) | KDM4EHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11280178 | 0.70 | MAPT (0.35) | KDM4ETSHRHTTMAPTSMN1; SMN2 | |
| SCHEMBL497608 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106892908-B | Synthetic method of 5- (8-bromo-2, 3-diphenyl quinoxaline-5-yl) thiophene-2-formaldehyde | 西安瑞联新材料股份有限公司 | 2021-04-06 | — | — | CN | claimed |
| US-11773074-B2 | Method for aerobic oxidative coupling of thiophenes with a ligand-supported palladium catalyst | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2023-10-03 | — | — | US | disclosed |
| US-11773074-B2 | Method for aerobic oxidative coupling of thiophenes with a ligand-supported palladium catalyst | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2023-10-03 | — | — | US | disclosed |
| CN-106892908-B | Synthetic method of 5- (8-bromo-2, 3-diphenyl quinoxaline-5-yl) thiophene-2-formaldehyde | 西安瑞联新材料股份有限公司 | 2021-04-06 | — | — | CN | disclosed |
| US-20210047285-A1 | Method for Aerobic Oxidative Coupling of Thiophenes with a Ligand-Supported Palladium Catalyst | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2021-02-18 | — | — | US | disclosed |
| US-10858334-B2 | Method for aerobic oxidative coupling of thiophenes with a ligand-supported palladium catalyst | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2020-12-08 | — | — | US | disclosed |
| WO-2020044213-A1 | DIPHENYLAMINO-METHYLENE MALONONITRILE BASED COMPOUNDS AS FLUORESCENCE PROBES | UNIVERSITY OF HYDERABAD (IN) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020044213-A1 | DIPHENYLAMINO-METHYLENE MALONONITRILE BASED COMPOUNDS AS FLUORESCENCE PROBES | UNIVERSITY OF HYDERABAD (IN) | 2020-03-05 | — | — | WO | disclosed |
| US-20190210993-A1 | Method for Aerobic Oxidative Coupling of Thiophenes with a Ligand-Supported Palladium Catalyst | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-07-11 | — | — | US | disclosed |
| US-10074813-B2 | Organic semiconductor composition and method for manufacturing organic semiconductor element | FUJIFILM CORPORATION (JP) | 2018-09-11 | — | — | US | disclosed |
| US-20020026052-A1 | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-02-28 | — | — | US | disclosed |
| CN-1332743-A | Cell adhesion-inhibiting antinflammatory compounds | ABBOTT CO (US) | 2002-01-23 | — | — | CN | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |
| EP-0714295-B1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2000-12-20 | — | — | EP | disclosed |
| EP-0714295-A4 | — | — | 1996-07-10 | — | — | EP | disclosed |
| EP-0714295-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5397791-A | Anticoagulants | MERCK & CO., INC. (US) | 1995-03-14 | — | — | US | disclosed |
| WO-1995004531-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-02-16 | — | — | WO | disclosed |
| EP-0596120-A1 | THIOPHENE COMPOUND | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |
| US-5185363-A | Administering for treatment of inflammatory diseases | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858334-B2 | Method for aerobic oxidative coupling of thiophenes with a ligand-supported palladium catalyst | PPOX, TST, COX6C | KDM4E 3896/4885TSHR 3137/4885HTT 1082/4885 |
| US-11773074-B2 | Method for aerobic oxidative coupling of thiophenes with a ligand-supported palladium catalyst | PPOX, TST, COX6C | KDM4E 3896/4885TSHR 3137/4885HTT 1082/4885 |
| US-20190210993-A1 | Method for Aerobic Oxidative Coupling of Thiophenes with a Ligand-Supported Palladium Catalyst | PPOX, TST, COX6C | KDM4E 3896/4885TSHR 3137/4885HTT 1082/4885 |
| US-10074813-B2 | Organic semiconductor composition and method for manufacturing organic semiconductor element | OR10J3, NR0B1, NR1H3 | KDM4E 2477/4885TSHR 1513/4885HTT 3621/4885 |
| US-20210047285-A1 | Method for Aerobic Oxidative Coupling of Thiophenes with a Ligand-Supported Palladium Catalyst | PPOX, TST, COX6C | KDM4E 3896/4885TSHR 3137/4885HTT 1082/4885 |
| US-20020026052-A1 | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | PKD1, PKD2, CSNK1A1 | KDM4E 1875/4885TSHR 1863/4885HTT 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.