Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.41 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6515018 | 0.83 | AKT2 (0.44) | AKT2PDPK1GSK3BNUDT1KIT | |
| SCHEMBL355788 | 0.81 | GSK3B (0.41) | PDPK1YTHDC1YTHDF2GSK3BNUDT1 | |
| SCHEMBL29923950 | 0.81 | GSK3B (0.41) | PDPK1YTHDC1YTHDF2GSK3BNUDT1 | |
| SCHEMBL16513126 | 0.78 | BRAF (0.45) | AKT2GSK3BKITTP53 | |
| SCHEMBL20420131 | 0.77 | YTHDC1 (0.49) | AKT2PDPK1YTHDC1YTHDF2CSF1R | |
| SCHEMBL30534246 | 0.75 | AKT2 (0.46) | AKT2PDPK1NUDT1KITJAK2 | |
| SCHEMBL26926539 | 0.74 | NUDT1 (0.37) | NUDT1XDHADORA3ADORA2AADORA1 | |
| SCHEMBL8009111 | 0.73 | CSF1R (0.71) | CSF1RALDH1A1CYP2C19CYP1A2CYP3A4 | |
| Adenine SCHEMBL11149448 | 0.73 | PI4KA (0.52) | PDPK1NUDT1XDHALDH1A1TP53 | |
| SCHEMBL1059581 | 0.72 | NUDT1 (0.68) | AKT2NUDT1XDHALDH1A1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018134148-A1 | SUBSTITUTED DIHYDROIMIDAZOPYRIDINEDIONES AS MKNK1 AND MKNK2 INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-26 | — | — | WO | disclosed |