Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11918991 | 0.81 | NUDT1 (0.36) | AKT2NUDT1ADORA2AADORA1PI4KA | |
| SCHEMBL6360434 | 0.81 | NUDT1 (0.36) | AKT2NUDT1ADORA2AADORA1CHEK1 | |
| SCHEMBL320848 | 0.81 | NUDT1 (0.43) | AKT2NUDT1ADORA2AADORA1PI4KA | |
| SCHEMBL30109321 | 0.78 | NUDT1 (0.68) | AKT2NUDT1ADORA2AADORA1HSP90AA1 | |
| SCHEMBL9544742 | 0.78 | AKT2 (0.44) | AKT2NUDT1ADORA3KITADORA2A | |
| SCHEMBL8906323 | 0.78 | AKT2 (0.44) | AKT2NUDT1ADORA3KITADORA2A | |
| SCHEMBL1059581 | 0.78 | NUDT1 (0.68) | AKT2NUDT1ADORA2AADORA1HSP90AA1 | |
| SCHEMBL3857164 | 0.78 | AKT2 (0.44) | AKT2NUDT1ADORA3KITADORA2A | |
| SCHEMBL21305258 | 0.78 | ADORA1 (0.50) | AKT2NUDT1ADORA3ADORA2AADORA1 | |
| SCHEMBL6515018 | 0.74 | AKT2 (0.44) | AKT2NUDT1ADORA3KITADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234942-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC THERAPEUTICS INC (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234942-A1 | COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | HTT, HYPK, CLN6 | AKT2 3059/4885NUDT1 802/4885ADORA3 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.