Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741648 | 0.79 | LMNA (0.61) | NR1H4ALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL20428405 | 0.76 | NR1H4 (0.41) | NR1H4ALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL21687439 | 0.73 | NR1H4 (0.41) | NR1H4ALDH1A1LMNAHTTMAPK1 | |
| SCHEMBL1107760 | 0.73 | NQO2 (0.63) | ALDH1A1LMNAMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL6341347 | 0.71 | TUBB4A (0.54) | ALDH1A1LMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL6938287 | 0.71 | GFER (0.54) | ALDH1A1LMNAHTTHPGDSMN1; SMN2 | |
| SCHEMBL6799209 | 0.70 | MAPT (0.52) | ALDH1A1HPGDSMN1; SMN2POLBMAPT | |
| SCHEMBL8628798 | 0.70 | APP (0.44) | ALDH1A1LMNAMAPK1HPGDPOLB | |
| SCHEMBL10829117 | 0.69 | CA1 (0.49) | ALDH1A1LMNAMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL9957765 | 0.69 | KDM4E (0.49) | ALDH1A1LMNAHTTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354648-A1 | 4-SUBSTITUED COUMARIN DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | Guizhou Bailing Group Pharmaceutical Co., Ltd. (CN) | 2018-08-01 | — | — | EP | disclosed |