Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | LIPE | Q05469 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16661210 | 0.85 | DGAT1 (0.38) | RAB9AKDM4EALDH1A1NPSR1POLB | |
| SCHEMBL18552799 | 0.84 | RAB9A (0.35) | RAB9AKDM4EALDH1A1NPSR1POLB | |
| SCHEMBL18552801 | 0.82 | PTGS2 (0.31) | KDM4EALDH1A1POLBHPGDKMT2A | |
| SCHEMBL16661275 | 0.81 | PDE10A (0.34) | — | |
| SCHEMBL20428575 | 0.77 | MEN1 (0.37) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL16661257 | 0.75 | DGAT1 (0.38) | RAB9AKDM4EALDH1A1NPSR1POLB | |
| SCHEMBL16660951 | 0.74 | KDM4E (0.31) | KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL18531176 | 0.73 | CYP2A6 (0.33) | RAB9AKMT2ANPC1MEN1 | |
| SCHEMBL20428777 | 0.72 | PTGS2 (0.33) | RAB9AKDM4EALDH1A1NPSR1POLB | |
| SCHEMBL16660946 | 0.70 | DGAT1 (0.39) | RAB9AKDM4EPOLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2862856-B1 | IMIDAZOLE AND TRIAZOLE COMPOUNDS AS DGAT-1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2018-08-01 | — | — | EP | disclosed |