SCHEMBL2043093

SCHEMBL2043093

C[Si](C)(C)ON=C(C(=NO[Si](C)(C)C)c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
GAA P10253 1/20 0.36
CYP2C19 P33261 1/20 0.36
TSHR P16473 3/20 0.35
ATM Q13315 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
F2 P00734 1/20 0.33
MAPT P10636 1/20 0.33
XDH P47989 1/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
TP53 P04637 1/20 0.32
CES2 O00748 2/20 0.32
CES1 P23141 2/20 0.32
ALDH1A1 P00352 2/20 0.32
DAO P14920 1/20 0.32
NAPRT Q6XQN6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2043092 1.00 LMNA (0.39) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL2048653 1.00 LMNA (0.39) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL9899300 0.87 CES2 (0.45) LMNAHTTL3MBTL1GAACYP2C19
SCHEMBL9899301 0.87 CES2 (0.45) LMNAHTTL3MBTL1GAACYP2C19
SCHEMBL212674 0.83 ALDH1A1 (0.41) LMNAMAPK1HTTL3MBTL1CYP2C19
SCHEMBL2052781 0.81 CYP2C19 (0.35) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL216241 0.81 LMNA (0.57) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL2052783 0.81 CYP2C19 (0.35) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL2050607 0.78 PPARA (0.44) LMNAMAPK1HTTL3MBTL1GAA
SCHEMBL2050606 0.78 PPARA (0.44) LMNAMAPK1HTTL3MBTL1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP claimed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US claimed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP claimed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US claimed
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP disclosed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US disclosed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP disclosed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US disclosed