Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15490628 | 0.89 | SPR (0.42) | RIPK1L3MBTL1SPREPHX2HSD11B1 | |
| SCHEMBL17034777 | 0.84 | RIPK1 (0.38) | RIPK1L3MBTL1EPHX2HSD11B1TP53 | |
| SCHEMBL16781413 | 0.83 | MEN1 (0.41) | RIPK1L3MBTL1EPHX2HSD11B1TP53 | |
| SCHEMBL15490630 | 0.81 | RORC (0.33) | RIPK1SPREPHX2HDAC6MEN1 | |
| SCHEMBL22991226 | 0.80 | RIPK1 (0.38) | RIPK1L3MBTL1EPHX2HSD11B1TP53 | |
| SCHEMBL15128218 | 0.79 | CYP3A4 (0.42) | SPREPHX2MEN1KMT2ACYP3A4 | |
| SCHEMBL30143045 | 0.79 | SPR (0.37) | L3MBTL1SPREPHX2MEN1KMT2A | |
| SCHEMBL24036283 | 0.78 | HPGD (0.44) | EPHX2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28882527 | 0.78 | HPGD (0.44) | EPHX2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL18309348 | 0.78 | LMNA (0.41) | SPREPHX2CYP3A4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2018-08-09 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222876-A1 | VINYL FLUORIDE CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | BACE1, BACE2, APP | RIPK1 3101/4885L3MBTL1 2738/4885SPR 2097/4885 |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | RIPK1 2632/4885L3MBTL1 1331/4885SPR 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.