Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | DDX3X | O00571 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22125270 | 0.80 | POLB (0.66) | TRPV1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL9400341 | 0.79 | ALDH1A1 (0.70) | TRPV1LMNASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1877761 | 0.77 | EPHX1 (0.73) | TRPV1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL30589624 | 0.77 | MEN1 (0.82) | TRPV1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL28914350 | 0.77 | MEN1 (0.82) | TRPV1LMNASMN1; SMN2KDM4EMAPT | |
| SCHEMBL22425034 | 0.77 | MAPT (0.77) | TRPV1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL1463506 | 0.75 | GRIK1 (0.73) | TRPV1LMNAKDM4EMAPTALDH1A1 | |
| SCHEMBL20442328 | 0.75 | TRPV1 (1.00) | TRPV1LMNAPOLBSMN1; SMN2KDM4E | |
| SCHEMBL22588913 | 0.75 | NPC1 (0.69) | TRPV1LMNAPOLBSMN1; SMN2MAPT | |
| SCHEMBL8421306 | 0.75 | SMN1; SMN2 (0.63) | TRPV1LMNAPOLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339122-B2 | hTRPV1 chemical agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210171454-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-06-10 | — | — | US | disclosed |
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-08-02 | — | — | US | disclosed |
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215705-A1 | hTRPV1 CHEMICAL AGENTS | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885LMNA 4320/4885POLB 4677/4885 |
| US-20210171454-A1 | hTRPV1 CHEMICAL AGENTS | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885LMNA 3964/4885POLB 4664/4885 |
| US-11339122-B2 | hTRPV1 chemical agents | TRPV1, TRPA1, TRPV4 | TRPV1 1/4885LMNA 4320/4885POLB 4677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.