Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 7/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2044456 | 1.00 | DNM1 (0.52) | DNM1FAAHTRPV1HTTSLC22A1 | |
| Hydrochloric Acid SCHEMBL2047104 | 1.00 | DNM1 (0.52) | DNM1FAAHTRPV1HTTSLC22A1 | |
| SCHEMBL8652742 | 0.98 | FAAH (0.54) | DNM1FAAHTRPV1HTTSLC22A1 | |
| Hydrochloric Acid SCHEMBL22022995 | 0.94 | TRPV1 (0.52) | TRPV1LMNAALOX15HSD17B10DUSP3 | |
| Hydrochloric Acid SCHEMBL20580816 | 0.94 | TRPV1 (0.52) | TRPV1LMNAALOX15HSD17B10DUSP3 | |
| Hydrochloric Acid SCHEMBL5673308 | 0.94 | HTT (0.60) | DNM1FAAHTRPV1HTTLMNA | |
| SCHEMBL19833609 | 0.91 | TRPV1 (0.53) | TRPV1LMNAALOX15HSD17B10DUSP3 | |
| Hydrochloric Acid SCHEMBL9814060 | 0.91 | FAAH (0.48) | DNM1FAAHTRPV1HTT | |
| Hydrochloric Acid SCHEMBL9814063 | 0.91 | FAAH (0.48) | DNM1FAAHTRPV1HTT | |
| SCHEMBL19833502 | 0.91 | TRPV1 (0.53) | TRPV1LMNAALOX15HSD17B10DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516511-B1 | THICKENER OR GELLANT FOR OIL MATERIALS, GEL COMPOSITION COMPRISING SAME, AND METHOD OF PRODUCING COSMETIC MATERIAL OR TOPICAL AGENT | DOW CORNING TORAY CO LTD (JP) | 2014-01-22 | — | — | EP | disclosed |
| US-8597619-B2 | Thickener or gellant for oil materials, gel composition comprising same, and method of producing cosmetic material or topical agent | Dow Corning Toray., Ltd. (JP) | 2013-12-03 | — | — | US | disclosed |
| US-20120328539-A1 | Thickener Or Gellant For Oil Materials, Gel Composition Comprising Same, And Method Of Producing Cosmetic Material Or Topical Agent | DOW TORAY CO., LTD. (JP) | 2012-12-27 | — | — | US | disclosed |
| EP-2516511-A2 | THICKENER OR GELLANT FOR OIL MATERIALS, GEL COMPOSITION COMPRISING SAME, AND METHOD OF PRODUCING COSMETIC MATERIAL OR TOPICAL AGENT | Dow Corning Toray Co., Ltd. (JP) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011078395-A2 | THICKENER OR GELLANT FOR OIL MATERIALS, GEL COMPOSITION COMPRISING SAME, AND METHOD OF PRODUCING COSMETIC MATERIAL OR TOPICAL AGENT | DOW CORNING TORAY CO., LTD. (JP) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120328539-A1 | Thickener Or Gellant For Oil Materials, Gel Composition Comprising Same, And Method Of Producing Cosmetic Material Or Topical Agent | H1-10, F12, RPS12 | DNM1 3635/4885FAAH 2793/4885TRPV1 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.