RPS12

Small ribosomal subunit protein eS12 · P25398 · RPS12 on Sugi Atlas →

3,676 patent compounds predicted against RPS12, 1,926 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL5500526	0.41	4/20
SCHEMBL5500532	0.41	4/20
SCHEMBL5503310	0.41	4/20
SCHEMBL11844361	0.35	4/20
SCHEMBL2000440	0.39	3/20
SCHEMBL8219903	0.36	3/20
SCHEMBL11627320	0.34	3/20
SCHEMBL10271044	0.55	2/20
SCHEMBL6394396	0.47	2/20
N-Methylpiperidine (SCHEMBL11205373)	0.42	2/20
Bicarbonate (SCHEMBL9058396)	0.42	2/20
SCHEMBL4960293	0.41	2/20
SCHEMBL4961968	0.40	2/20
SCHEMBL6686992	0.40	2/20
SCHEMBL9429122	0.38	2/20
Chloramphenicol (SCHEMBL10796001)	1.00	1/20
Geneticin (SCHEMBL15596)	0.93	1/20
Geneticin (SCHEMBL5006573)	0.93	1/20
Geneticin (SCHEMBL9920496)	0.93	1/20
Chloramphenicol (SCHEMBL16111)	0.90	1/20

Clinical trials — most relevant to RPS12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris	PHASE4	UNKNOWN
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Cixutumumab and Temsirolimus in Treating Patients With Metastatic Prostate Cancer	PHASE1/PHASE2	COMPLETED
Study of GnRH-A [Leuprorelin(Lorelin Depot] Plus Leterozole +/- Everolimus for Premenopausal Women With Metastatic Breast Cancer	PHASE2	COMPLETED
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients	PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma	PHASE1/PHASE2	COMPLETED
Study of Decitabine in Combination With Sequential Rapamycin or Ribavirin in High Risk AML Patients	PHASE1/PHASE2	COMPLETED
A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis	PHASE1/PHASE2	COMPLETED
ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia	PHASE1	RECRUITING
Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	PHASE1	WITHDRAWN
Testing of Micellar Casein, Blended Micellar Casein and Native Whey	nan	COMPLETED
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care	nan	COMPLETED
Micro Ribosomal Nucleic Acid 155 in Non Hodgkin Lymphoma	nan	COMPLETED
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)	nan	RECRUITING
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer	nan	WITHDRAWN
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN
The Effects of Whey vs. Collagen on MPS	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory	nan	COMPLETED
RibOSE - Glucose and Resistance Exercise Training	nan	COMPLETED
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children	nan	COMPLETED
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a RPS12 binder may also engage these)

Protein	Name	Similarity
P63323	—	1.000	P63323 →
Q76I81	—	1.000	Q76I81 →
G1SFR8	—	1.000	G1SFR8 →
P46405	—	1.000	P46405 →
P47840	—	1.000	P47840 →
P63324	—	1.000	P63324 →
P84175	—	1.000	P84175 →
O13019	—	0.998	O13019 →
Q9SMI3	—	0.989	Q9SMI3 →
Q9XHS0	—	0.989	Q9XHS0 →
Q9SKZ3	—	0.978	Q9SKZ3 →
O59936	—	0.977	O59936 →
P80455	—	0.976	P80455 →
Q54PX9	—	0.975	Q54PX9 →
Q9M5M6	—	0.974	Q9M5M6 →
O74322	—	0.974	O74322 →
Q9S9P1	—	0.974	Q9S9P1 →
O14062	—	0.971	O14062 →
Q9LEY9	—	0.971	Q9LEY9 →
Q5ADQ6	—	0.971	Q5ADQ6 →
O49884	—	0.969	O49884 →
P49196	—	0.969	P49196 →
Q29375	—	0.967	Q29375 →
NAT10	RNA cytidine acetyltransferase	0.966	landscape →
Q8VZ19	—	0.965	Q8VZ19 →
Q03253	—	0.964	Q03253 →
A6QLJ3	—	0.963	A6QLJ3 →
O48558	—	0.963	O48558 →
P31478	—	0.963	P31478 →
Q9P7H0	—	0.963	Q9P7H0 →