Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2041332 | 0.81 | NPSR1 (0.68) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2049067 | 0.81 | HSD17B10 (0.52) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2043814 | 0.79 | NPSR1 (0.61) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL16041039 | 0.78 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2045682 | 0.73 | MAPT (0.54) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2049069 | 0.73 | NPSR1 (0.50) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2045132 | 0.73 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL2036868 | 0.73 | MAPT (0.59) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL20850459 | 0.73 | CA12 (0.67) | NPC1RAB9ASMN1; SMN2PKMALDH1A1 | |
| SCHEMBL5175009 | 0.71 | MEN1 (0.42) | RAB9AMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516398-B1 | PHENOLIC DERIVATIVES, AND THEIR PHARMACEUTICAL OR COSMETIC USE | GALDERMA RES & DEV (FR) | 2018-03-21 | — | — | EP | claimed |
| US-9505720-B2 | Phenol derivatives and pharmaceutical or cosmetic use thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-11-29 | — | — | US | claimed |
| US-20160115132-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-04-28 | — | — | US | claimed |
| US-9050266-B2 | Phenol derivatives and pharmaceutical or cosmetic use thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-06-09 | — | — | US | claimed |
| US-20140275536-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-09-18 | — | — | US | claimed |
| EP-2516398-A2 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | Galderma Research & Development (FR) | 2012-10-31 | — | — | EP | claimed |
| WO-2011077043-A2 | PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-06-30 | — | — | WO | claimed |
| EP-2516398-B1 | PHENOLIC DERIVATIVES, AND THEIR PHARMACEUTICAL OR COSMETIC USE | GALDERMA RES & DEV (FR) | 2018-03-21 | — | — | EP | disclosed |
| US-20170037015-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-02-09 | — | — | US | disclosed |
| US-9505720-B2 | Phenol derivatives and pharmaceutical or cosmetic use thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-11-29 | — | — | US | disclosed |
| US-20160115132-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2016-04-28 | — | — | US | disclosed |
| US-9050266-B2 | Phenol derivatives and pharmaceutical or cosmetic use thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-06-09 | — | — | US | disclosed |
| US-20140275536-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-09-18 | — | — | US | disclosed |
| EP-2516398-A2 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | Galderma Research & Development (FR) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011077043-A2 | PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037015-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | TYR, MITF, TEAD3 | NPC1 799/4885RAB9A 2368/4885SMN1; SMN2 4792/4885 |
| US-20140275536-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | TYR, MITF, CUTA | NPC1 1091/4885RAB9A 2761/4885SMN1; SMN2 4402/4885 |
| US-20160115132-A1 | NOVEL PHENOL DERIVATIVES AND PHARMACEUTICAL OR COSMETIC USE THEREOF | TYR, MITF, TEAD3 | NPC1 799/4885RAB9A 2368/4885SMN1; SMN2 4792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.