Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | YAP1 | P46937 | 3/20 | 0.51 |
| ▸ | TEAD4 | Q15561 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | RNF4 | P78317 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13396259 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL25252107 | 0.88 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL8922383 | 0.86 | ATM (0.43) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL29497016 | 0.79 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL3315879 | 0.74 | KMT2A (0.49) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL26618380 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTKMT2ATDP1 | |
| SCHEMBL26618376 | 0.73 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HTTKMT2ATDP1 | |
| SCHEMBL31581706 | 0.72 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL31564673 | 0.72 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 | |
| SCHEMBL4573275 | 0.72 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTYAP1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142655-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |
| US-10544120-B2 | Biaryl kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-01-28 | — | — | US | disclosed |
| EP-3356340-B1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-10-23 | — | — | EP | disclosed |
| US-20180346440-A1 | BIARYL KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-12-06 | — | — | US | disclosed |
| EP-3356340-A1 | BIARYL KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2018-08-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180346440-A1 | BIARYL KINASE INHIBITORS | AAK1, CAMKK1, CAMKK2 | ALDH1A1 2360/4885SMN1; SMN2 1356/4885HTT 1044/4885 |
| US-10544120-B2 | Biaryl kinase inhibitors | AAK1, CAMKK1, CAMKK2 | ALDH1A1 2360/4885SMN1; SMN2 1356/4885HTT 1044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.