Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | YAP1 | P46937 | 4/20 | 0.53 |
| ▸ | TEAD4 | Q15561 | 4/20 | 0.53 |
| ▸ | RNF4 | P78317 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252107 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL29497016 | 0.88 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL20447205 | 0.88 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL3315879 | 0.87 | KMT2A (0.49) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL31581706 | 0.74 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL31564673 | 0.74 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL4573275 | 0.74 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL4573265 | 0.74 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL8922383 | 0.73 | ATM (0.43) | SMN1; SMN2ALDH1A1HTTYAP1TEAD4 | |
| SCHEMBL26618380 | 0.72 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HTTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105654-A1 | SUBSTITUTED QUINAZOLINONE COMPOUNDS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-04-29 | — | — | US | disclosed |
| US-20100105654-A1 | SUBSTITUTED QUINAZOLINONE COMPOUNDS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2010-04-29 | — | — | US | disclosed |
| US-7625909-B2 | Substituted quinazolinone compounds | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625909-B2 | Substituted quinazolinone compounds | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7368453-B2 | Quinazolinone compounds with reduced bioaccumulation | CHIRON CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368453-B2 | Quinazolinone compounds with reduced bioaccumulation | CHIRON CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105654-A1 | SUBSTITUTED QUINAZOLINONE COMPOUNDS | MC4R, MC5R, MC2R | SMN1; SMN2 2226/4885ALDH1A1 4209/4885HTT 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.