Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9230833 | 0.79 | KMT2A (0.51) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL29666377 | 0.79 | KMT2A (0.51) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL17839656 | 0.79 | KMT2A (0.51) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL4654255 | 0.77 | DRD1 (0.48) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL11918910 | 0.76 | ALDH1A1 (0.58) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL10310198 | 0.76 | KMT2A (0.56) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL12845223 | 0.76 | KMT2A (0.65) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL7710363 | 0.75 | TSHR (0.56) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL21966132 | 0.75 | ALOX12 (0.52) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 | |
| SCHEMBL11915498 | 0.75 | KMT2A (0.47) | KMT2AHTTSMN1; SMN2ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516419-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-10-31 | — | — | EP | disclosed |
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2012-09-27 | — | — | US | disclosed |
| WO-2011079102-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | SANOFI (FR) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245161-A1 | INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS | TPSAB1, TPSB2, TPSD1 | KMT2A 1278/4885HTT 1251/4885SMN1; SMN2 3938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.