Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18788145 | 0.67 | GRM2 (0.46) | MAPK13MAPK12MAPK11MAPK14POLB | |
| SCHEMBL18788152 | 0.65 | USP2 (0.57) | KMT2APKMHTTALDH1A1HPGD | |
| SCHEMBL11865563 | 0.63 | GAA (0.41) | KMT2ALMNAPOLBNPC1HTT | |
| SCHEMBL5457663 | 0.63 | NPC1 (0.52) | KMT2ALMNAXDHPOLBNPC1 | |
| SCHEMBL325655 | 0.63 | KMT2A (0.50) | KMT2APOLBL3MBTL1GAAALDH1A1 | |
| SCHEMBL11859835 | 0.62 | CHRNB2 (0.41) | KMT2APKMHTTL3MBTL1GAA | |
| SCHEMBL11840254 | 0.61 | HCAR1 (0.47) | KMT2ALMNAXDHPOLBNPC1 | |
| SCHEMBL11394388 | 0.61 | HCAR1 (0.45) | KMT2ALMNAPOLBHTTALDH1A1 | |
| SCHEMBL11248751 | 0.60 | ALDH1A1 (0.43) | KMT2ALMNAPOLBNPC1HTT | |
| SCHEMBL11855513 | 0.60 | HTT (0.37) | KMT2ALMNAXDHPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356345-A1 | HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2018-08-08 | — | — | EP | disclosed |