Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.31 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.32 |
| ▸ | RAD52 | P43351 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329178 | 0.98 | HTT (0.35) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Water SCHEMBL15571107 | 0.96 | HTT (0.34) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL202419 | 0.96 | HTT (0.34) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Iodide SCHEMBL1226177 | 0.96 | HTT (0.35) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL31207589 | 0.94 | CA1 (0.41) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL8873590 | 0.92 | HTT (0.44) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL193259 | 0.92 | HTT (0.44) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL15798390 | 0.92 | HTT (0.44) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL9194597 | 0.92 | HTT (0.44) | CA1CA2HTTSMN1; SMN2NPC1 | |
| Bromide SCHEMBL17027655 | 0.92 | HTT (0.44) | CA1CA2HTTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111584891-B | Atomic-level iron active site catalyst and preparation method and application thereof | 南通大学 | 2022-02-01 | — | — | CN | disclosed |
| CN-111584891-A | Atomic-level iron active site catalyst and preparation method and application thereof | 南通大学 | 2020-08-25 | — | — | CN | disclosed |
| EP-2181979-B1 | Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin | DOW GLOBAL TECHNOLOGIES LLC (US) | 2015-04-22 | — | — | EP | disclosed |
| EP-2174925-B1 | Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin | DOW GLOBAL TECHNOLOGIES LLC (US) | 2014-10-15 | — | — | EP | disclosed |
| US-8404905-B2 | Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloroacetone levels | DOW GLOBAL TECHNOLOGIES LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-8304563-B2 | Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloroacetone levels | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-8236975-B2 | Process for the conversion of a crude glycerol, crude mixtures of naturally derived multicomponent aliphatic hydrocarbons or esters thereof to a chlorohydrin | DOW GLOBAL TECHNOLOGIES LLC | 2012-08-07 | — | — | US | disclosed |
| WO-2012006313-A2 | HERBICIDAL COMPOSITIONS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2012-01-12 | — | — | WO | disclosed |
| US-8088957-B2 | Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin | DOW GLOBAL TECHNOLOGIES LLC | 2012-01-03 | — | — | US | disclosed |
| US-20110178315-A1 | PROCESS FOR THE CONVERSION OF A CRUDE GLYCEROL, CRUDE MIXTURES OF NATURALLY DERIVED MULTICOMPONENT ALIPHATIC HYDROCARBONS OR ESTERS THEREOF TO A CHLOROHYDRIN | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-07-21 | — | — | US | disclosed |
| US-7910781-B2 | Process for the conversion of a crude glycerol, crude mixtures of naturally derived multihydroxylated aliphatic hydrocarbons or esters thereof to a chlorohydrin | DOW GLOBAL TECHNOLOGIES LLC | 2011-03-22 | — | — | US | disclosed |
| US-7906690-B2 | Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels | DOW GLOBAL TECHNOLOGIES INC. | 2011-03-15 | — | — | US | disclosed |
| EP-2181979-A1 | Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin | Dow Global Technologies Inc. (US) | 2010-05-05 | — | — | EP | disclosed |
| EP-2174925-A1 | Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin | Dow Global Technologies Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| EP-1771403-B1 | CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-01-06 | — | — | EP | disclosed |
| US-20080045728-A1 | Conversion of a Multihydroxylated-Aliphatic Hydrocarbon or Ester Thereof to a Chlorohydrin | BLUE CUBE IP LLC | 2008-02-21 | — | — | US | disclosed |
| US-20080015370-A1 | Process for the conversion of a crude glycerol, crude mixtures of naturally derived multicomponent aliphatic hydrocarbons or esters thereof to a chlorohydrin | BLUE CUBE IP LLC | 2008-01-17 | — | — | US | disclosed |
| US-20080015369-A1 | Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels | BLUE CUBE IP LLC | 2008-01-17 | — | — | US | disclosed |
| EP-1771403-A1 | CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN | Dow Gloval Technologies Inc. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006020234-A1 | CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN | DOW GLOBAL TECHNOLOGIES INC. (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015370-A1 | Process for the conversion of a crude glycerol, crude mixtures of naturally derived multicomponent aliphatic hydrocarbons or esters thereof to a chlorohydrin | GK, CETP, CYP46A1 | CHRM2 2976/4885CHRM4 3103/4885CHRM5 3633/4885 |
| US-20080045728-A1 | Conversion of a Multihydroxylated-Aliphatic Hydrocarbon or Ester Thereof to a Chlorohydrin | CHN2, HDHD5, ASPH | CHRM2 3713/4885CHRM4 3607/4885CHRM5 4240/4885 |
| US-20110178315-A1 | PROCESS FOR THE CONVERSION OF A CRUDE GLYCEROL, CRUDE MIXTURES OF NATURALLY DERIVED MULTICOMPONENT ALIPHATIC HYDROCARBONS OR ESTERS THEREOF TO A CHLOROHYDRIN | GK, CETP, CYP46A1 | CHRM2 2976/4885CHRM4 3103/4885CHRM5 3633/4885 |
| US-20080015369-A1 | Batch, semi-continuous or continuous hydrochlorination of glycerin with reduced volatile chlorinated hydrocarbon by-products and chloracetone levels | GK, GLI2, CHLSN | CHRM2 992/4885CHRM4 1321/4885CHRM5 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.