Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14924073 | 0.90 | KDM2B (0.48) | HPGDSMN1; SMN2ALDH1A1LMNAKDM2B | |
| SCHEMBL20457853 | 0.89 | NPC1 (0.40) | HPGDSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL17660585 | 0.86 | KDM4E (0.37) | HPGDSMN1; SMN2ALDH1A1LMNAKDM2B | |
| SCHEMBL17660584 | 0.86 | ABCB1 (0.47) | KDM2BTSHRMAPT | |
| SCHEMBL17665062 | 0.84 | SMN1; SMN2 (0.49) | HPGDSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL1104672 | 0.83 | SMN1; SMN2 (0.52) | HPGDSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL14924068 | 0.82 | L3MBTL3 (0.46) | HPGDSMN1; SMN2ALDH1A1TSHRMAPT | |
| SCHEMBL17630357 | 0.81 | ALDH1A1 (0.57) | HPGDSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL14924049 | 0.81 | L3MBTL3 (0.45) | HPGDSMN1; SMN2ALDH1A1TSHRMAPT | |
| SCHEMBL17660589 | 0.80 | L3MBTL1 (0.48) | SMN1; SMN2ALDH1A1LMNAKDM2BCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253019-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253019-B2 | Tank-binding kinase inhibitor compounds | TBKBP1, TNKS1BP1, TNKS | HPGD 4072/4885SMN1; SMN2 2291/4885ALDH1A1 4260/4885 |
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | TBKBP1, TNKS1BP1, TNKS | HPGD 4072/4885SMN1; SMN2 2291/4885ALDH1A1 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.