Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | MPI | P34949 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514468 | 0.78 | PRKDC (0.52) | NPC1LMNAMAPTKMT2ATP53 | |
| SCHEMBL20460320 | 0.77 | KDM4E (0.67) | RAB9AL3MBTL1PAX8NPC1HTT | |
| SCHEMBL20460271 | 0.76 | KDM4E (0.65) | NPC1HTTSMN1; SMN2LMNAMAPT | |
| SCHEMBL12530876 | 0.76 | METAP2 (0.54) | RAB9AL3MBTL1PAX8NPC1HTT | |
| SCHEMBL31428721 | 0.76 | ALDH1A1 (0.69) | RAB9AL3MBTL1PAX8NPC1SMN1; SMN2 | |
| SCHEMBL23714056 | 0.75 | L3MBTL1 (0.59) | RAB9AL3MBTL1PAX8NPC1HTT | |
| SCHEMBL16964453 | 0.75 | HTR1A (0.60) | RAB9AL3MBTL1NPC1HTTSMN1; SMN2 | |
| SCHEMBL14514792 | 0.75 | CYP2A13 (0.63) | L3MBTL1KMT2AKDM4EDRD2DRD4 | |
| SCHEMBL24716123 | 0.75 | POLB (0.59) | RAB9AL3MBTL1PAX8NPC1HTT | |
| SCHEMBL30626612 | 0.75 | POLB (0.59) | RAB9AL3MBTL1PAX8NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288351-B1 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2018-08-08 | — | — | EP | disclosed |