Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18440704 | 0.89 | RORC (0.53) | KMT2ARAB9AMAPTKDM4EMEN1 | |
| SCHEMBL20465143 | 0.86 | MAPT (0.48) | KMT2ARAB9AMAPTKDM4EMEN1 | |
| SCHEMBL18440701 | 0.85 | RORC (0.55) | SRD5A2KMT2ARORCALDH1A1IDH1 | |
| SCHEMBL20465183 | 0.83 | RORC (0.42) | KMT2ARAB9AMAPTKDM4EMEN1 | |
| SCHEMBL19360604 | 0.83 | IDH1 (0.47) | RORCIDH1 | |
| SCHEMBL20465180 | 0.79 | IDH1 (0.48) | SRD5A2RORCALDH1A1IDH1SMN1; SMN2 | |
| SCHEMBL19360401 | 0.79 | RORC (0.51) | RORC | |
| SCHEMBL19360349 | 0.78 | RORC (0.68) | RORC | |
| SCHEMBL14549402 | 0.78 | KMT2A (0.51) | KMT2ARAB9AMAPTKDM4EMEN1 | |
| SCHEMBL18440697 | 0.77 | RORC (0.50) | KMT2ARAB9AMAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222860-A1 | MODULATORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, LLC | 2018-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222860-A1 | MODULATORS OF ROR-GAMMA | RORB, RORC, RORA | SRD5A2 144/4885KMT2A 2604/4885RAB9A 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.