Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30449704 | 0.77 | HTR7 (0.44) | PTGS2HTR7ALDH1A1PDE5ADRD2 | |
| SCHEMBL8083455 | 0.77 | ALDH1A1 (0.41) | PTGS2HTR7ALDH1A1PDE5ADRD2 | |
| SCHEMBL30548746 | 0.74 | PTGS2 (0.55) | PTGS2HTR7ALDH1A1PDE5ADRD2 | |
| SCHEMBL10350653 | 0.74 | PTGS2 (0.55) | PTGS2HTR7ALDH1A1PDE5ADRD2 | |
| SCHEMBL10144088 | 0.71 | PTGS2 (0.49) | PTGS2HTR7ALDH1A1PDE5ADRD2 | |
| SCHEMBL3249842 | 0.70 | TDP1 (0.56) | PTGS2ALDH1A1LMNA | |
| SCHEMBL16279674 | 0.69 | PTGS2 (0.39) | PTGS2ALDH1A1MAOAMAOBCA12 | |
| SCHEMBL3628525 | 0.67 | MEN1 (0.54) | PTGS2ALDH1A1PDE5AHTTSOAT1 | |
| SCHEMBL31462333 | 0.67 | PTGS2 (0.41) | PTGS2HTR7ALDH1A1PDE5AMAOA | |
| SCHEMBL28503485 | 0.67 | PTGS2 (0.41) | PTGS2HTR7ALDH1A1PDE5AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018144717-A1 | NEW PLEUROMUTILIN ANTIBIOTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE AND SYNTHESIS | YALE UNIVERSITY (US) | 2018-08-09 | — | — | WO | disclosed |