SCHEMBL8083455

SCHEMBL8083455

CCCSc1cccc(Cl)c1C

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
PTGS2 P35354 2/20 0.40
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HTT P42858 1/20 0.37
LMNA P02545 1/20 0.34
POLB P06746 1/20 0.34
APLNR P35414 1/20 0.34
HTR7 P34969 1/20 0.33
PDE5A O76074 1/20 0.33
DRD2 P14416 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8088430 0.84 ALDH1A1 (0.43) ALDH1A1MAPTSMN1; SMN2HTTLMNA
SCHEMBL10144132 0.82 PTGS2 (0.47) ALDH1A1PTGS2MAPTSMN1; SMN2LMNA
SCHEMBL8083496 0.78 ALDH1A1 (0.38) ALDH1A1MAPTSMN1; SMN2
SCHEMBL30449704 0.77 HTR7 (0.44) ALDH1A1PTGS2MAPTLMNAAPLNR
SCHEMBL20467775 0.77 PTGS2 (0.40) ALDH1A1PTGS2HTTLMNAAPLNR
SCHEMBL31717936 0.74 ALDH1A1 (0.50) ALDH1A1PTGS2MAPTSMN1; SMN2LMNA
SCHEMBL944379 0.74 ALDH1A1 (0.50) ALDH1A1PTGS2MAPTSMN1; SMN2LMNA
SCHEMBL30548746 0.74 PTGS2 (0.55) ALDH1A1PTGS2HTR7PDE5ADRD2
SCHEMBL10350653 0.74 PTGS2 (0.55) ALDH1A1PTGS2HTR7PDE5ADRD2
SCHEMBL351155 0.73 CYP1A2 (0.50) ALDH1A1MAPTSMN1; SMN2LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1044980-A1 PROCESS FOR PRODUCING TOLUENE DERIVATIVES Ihara Chemical Industry Co., Ltd. (JP) 2000-10-18 EP disclosed