SCHEMBL20471850

SCHEMBL20471850

CC(C)(C)OC(=O)N1CC[C@H](O[Si](C)(C)C(C)(C)C)[C@H]1/C=C/C(=O)O

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.34
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
ALDH1A1 P00352 2/20 0.33
RECQL P46063 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
USP2 O75604 1/20 0.32
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
GRM5 P41594 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20471851 1.00 HSD17B10 (0.34) HSD17B10CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL25280480 0.93 HSD17B10 (0.40) HSD17B10ALDH1A1SMN1; SMN2MEN1LMNA
SCHEMBL20471741 0.93 HSD17B10 (0.40) HSD17B10ALDH1A1SMN1; SMN2MEN1LMNA
SCHEMBL20471739 0.93 HSD17B10 (0.40) HSD17B10ALDH1A1SMN1; SMN2MEN1LMNA
SCHEMBL820844 0.85 ALDH1A1 (0.36) ALDH1A1MEN1LMNATSHRKMT2A
SCHEMBL375388 0.85 ALDH1A1 (0.36) ALDH1A1MEN1LMNATSHRKMT2A
SCHEMBL375387 0.85 ALDH1A1 (0.36) ALDH1A1MEN1LMNATSHRKMT2A
SCHEMBL7874264 0.85 CHRM2 (0.36) HSD17B10CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL817959 0.85 CHRM2 (0.36) HSD17B10CHRM2CHRM1CHRM3ALDH1A1
SCHEMBL144260 0.85 CHRM2 (0.36) HSD17B10CHRM2CHRM1CHRM3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110191882-B Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them 株式会社大熊制药 2022-09-13 CN disclosed
US-10981917-B2 Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2021-04-20 US disclosed
WO-2018147626-A1 NOVEL HETEROCYCLIC COMPOUND, ITS PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2018-08-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10981917-B2 Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same RNASE1, AARS1, DHPS HSD17B10 659/4885CHRM2 4871/4885CHRM1 4823/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.