Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | TSPO | P30536 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30842223 | 0.93 | TSPO (0.42) | MMP1MMP9MMP13TSPOMAPK8 | |
| SCHEMBL20475942 | 0.93 | TSPO (0.42) | MMP1MMP9MMP13TSPOMAPK8 | |
| SCHEMBL29920814 | 0.89 | TSPO (0.39) | MMP1MMP9MMP13TSPOMAPK8 | |
| SCHEMBL21949797 | 0.89 | TSPO (0.39) | MMP1MMP9MMP13TSPOMAPK8 | |
| SCHEMBL20476279 | 0.85 | NLRP3 (0.39) | MMP1MMP9MMP13TSPOLMNA | |
| SCHEMBL20475954 | 0.80 | MAPK8 (0.39) | MMP1MMP9MMP13MAPK8PIK3R1 | |
| SCHEMBL30842235 | 0.78 | TLR7 (0.51) | TLR7 | |
| SCHEMBL20741482 | 0.78 | TLR7 (0.51) | TLR7 | |
| SCHEMBL19503120 | 0.78 | TLR7 (0.49) | PDE1BTLR7RXFP1 | |
| SCHEMBL29280825 | 0.77 | PIK3R1 (0.42) | MAPK8PIK3R1PIK3CAPDE1BTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067649-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2024-02-29 | — | — | US | disclosed |
| US-11827632-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2023-11-28 | — | — | US | disclosed |
| EP-3753938-A1 | SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS | Innate Tumor Immunity, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200157096-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2020-05-21 | — | — | US | disclosed |
| EP-3510034-B1 | SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3510034-A1 | SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS | Innate Tumor Immunity, Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| US-20190055236-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. | 2019-02-21 | — | — | US | disclosed |
| WO-2018152396-A1 | SUBSTITUTED IMIDAZO-QUINOLINES AS NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2018-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827632-B2 | NLRP3 modulators | NLRP3, NLRP1, NOD1 | MMP1 4572/4885MMP9 4570/4885MMP13 4327/4885 |
| US-20190055236-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, NOD1 | MMP1 4572/4885MMP9 4570/4885MMP13 4327/4885 |
| US-20200157096-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, NOD1 | MMP1 4572/4885MMP9 4570/4885MMP13 4327/4885 |
| US-20240067649-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, NOD1 | MMP1 4572/4885MMP9 4570/4885MMP13 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.