Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | TEC | P42680 | 3/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16143478 | 1.00 | BTK (0.42) | BTKLCKTECERBB2TXK | |
| SCHEMBL15156546 | 0.93 | EGFR (0.44) | BTKLCKTECEGFRSRC | |
| SCHEMBL19209529 | 0.93 | TLR7 (0.41) | BTKLCKTECERBB2TXK | |
| SCHEMBL18618395 | 0.85 | BTK (0.55) | BTKLCKTECERBB2TXK | |
| SCHEMBL15145742 | 0.84 | SRC (0.55) | EGFRSRC | |
| SCHEMBL15156055 | 0.84 | SRC (0.55) | EGFRSRC | |
| SCHEMBL23803929 | 0.79 | ADORA3 (0.49) | LCKTLR7EGFRSRCFYN | |
| SCHEMBL28881338 | 0.79 | SRC (0.50) | EGFRSRC | |
| SCHEMBL28117979 | 0.78 | TLR7 (0.45) | BTKLCKTLR7EGFRSRC | |
| SCHEMBL16321781 | 0.78 | SRC (0.49) | BTKTECEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180243311-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | GILEAD SCIENCES, INC. | 2018-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180243311-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, ABL1, LYN | BTK 1/4885LCK 5/4885TEC 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.