Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 8/20 | 0.38 |
| ▸ | EGFR | P00533 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 8/20 | 0.38 |
| ▸ | ABL2 | P42684 | 8/20 | 0.38 |
| ▸ | AMD1 | P17707 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28832955 | 0.94 | TLR7 (0.43) | TLR7ABL1EGFRSRCABL2 | |
| SCHEMBL16143478 | 0.78 | BTK (0.42) | TLR7EGFRSRCLCKBTK | |
| SCHEMBL20480733 | 0.78 | BTK (0.42) | TLR7EGFRSRCLCKBTK | |
| SCHEMBL23803929 | 0.77 | ADORA3 (0.49) | TLR7ABL1EGFRSRCPIK3CD | |
| SCHEMBL19209529 | 0.75 | TLR7 (0.41) | TLR7EGFRSRCAMD1PIK3CD | |
| SCHEMBL30563726 | 0.75 | TLR7 (0.44) | TLR7AMD1TLR8NSD2NSD3 | |
| SCHEMBL18618395 | 0.75 | BTK (0.55) | TLR7EGFRLCKBTK | |
| SCHEMBL15145742 | 0.74 | SRC (0.55) | ABL1EGFRSRCABL2PIK3CD | |
| SCHEMBL15156546 | 0.74 | EGFR (0.44) | EGFRSRCLCKBTK | |
| SCHEMBL25269666 | 0.73 | MTOR (0.44) | TLR7AMD1PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279172-A | Purinone compound as inhibitors of kinases | 药品循环有限责任公司 | 2017-01-04 | — | — | CN | disclosed |
| CN-104640861-B | Purinone compounds as kinase inhibitors | 药品循环公司 | 2016-08-24 | — | — | CN | disclosed |