Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482672 | 0.82 | REN (0.46) | RENSIGMAR1ALDH1A1SMPD1HDAC1 | |
| SCHEMBL20482779 | 0.82 | REN (0.47) | RENSIGMAR1SMPD1HDAC1HDAC8 | |
| SCHEMBL20482240 | 0.82 | REN (0.41) | RENSIGMAR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL20482988 | 0.81 | HTR1A (0.40) | ALDH1A1KMT2ASMN1; SMN2MEN1SMPD1 | |
| SCHEMBL20482607 | 0.80 | REN (0.42) | RENSIGMAR1SIRT2 | |
| SCHEMBL20482799 | 0.78 | REN (0.39) | REN | |
| SCHEMBL20482792 | 0.77 | REN (0.40) | RENKMT2ALMNAHTT | |
| SCHEMBL20482885 | 0.77 | KMT2A (0.48) | SIRT2ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL20482372 | 0.77 | REN (0.40) | RENKMT2AMEN1 | |
| SCHEMBL20482692 | 0.76 | KMT2A (0.47) | SIRT2ALDH1A1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |