Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20482692 | 0.88 | KMT2A (0.47) | KMT2AKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL20482988 | 0.86 | HTR1A (0.40) | KMT2AKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL20482556 | 0.84 | ALDH1A1 (0.46) | KMT2AKDM4ESMN1; SMN2ALDH1A1HDAC1 | |
| SCHEMBL20482226 | 0.83 | HPGD (0.40) | KMT2AKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL20482809 | 0.83 | PTPN1 (0.40) | KMT2ASMN1; SMN2LMNAHTTALDH1A1 | |
| SCHEMBL20482270 | 0.81 | RXRA (0.42) | HTTALDH1A1L3MBTL1 | |
| SCHEMBL20482481 | 0.79 | MAPK1 (0.53) | KMT2AKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL20482240 | 0.78 | REN (0.41) | KMT2AALDH1A1MEN1L3MBTL1NPC1 | |
| SCHEMBL20482676 | 0.78 | SMPD1 (0.52) | KMT2AKDM4ESMN1; SMN2LMNABCHE | |
| SCHEMBL20482446 | 0.78 | TSHR (0.38) | KMT2ASMN1; SMN2LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018154466-A1 | DIHYDROQUINOLIZINONES AS ANTIVIRALS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-08-30 | — | — | WO | disclosed |