SCHEMBL2048264

SCHEMBL2048264

CSc1ccccc1Oc1nnc(Cl)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
SMN1; SMN2 Q16637 5/20 0.39
KDM4E B2RXH2 4/20 0.39
HPGD P15428 4/20 0.39
ALDH1A1 P00352 7/20 0.38
RAB9A P51151 4/20 0.38
NPC1 O15118 3/20 0.38
AR P10275 1/20 0.37
PKM P14618 1/20 0.36
LMNA P02545 1/20 0.36
ADRB2 P07550 1/20 0.36
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
HTT P42858 1/20 0.36
KMT2A Q03164 4/20 0.35
MEN1 O00255 3/20 0.35
POLB P06746 1/20 0.35
IDO1 P14902 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2047147 0.86 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3SMN1; SMN2KDM4E
SCHEMBL2050373 0.80 SMN1; SMN2 (0.50) SLC6A2SLC6A4SLC6A3SMN1; SMN2KDM4E
SCHEMBL27413723 0.75 SMN1; SMN2 (0.51) SLC6A2SLC6A4SLC6A3SMN1; SMN2KDM4E
SCHEMBL2051104 0.75 LMNA (0.35) SLC6A2SLC6A4SLC6A3SMN1; SMN2NPC1
SCHEMBL2774997 0.74 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3SMN1; SMN2KDM4E
SCHEMBL10321158 0.74 SMN1; SMN2 (0.43) SMN1; SMN2NPC1LMNAMAPTHTT
SCHEMBL2048822 0.74 HSD11B1 (0.41) KDM4EHPGDALDH1A1RAB9ALMNA
SCHEMBL2047742 0.74 LMNA (0.34) SMN1; SMN2KDM4EHPGDALDH1A1RAB9A
SCHEMBL2048957 0.74 ALDH1A1 (0.36) SMN1; SMN2HPGDALDH1A1RAB9ANPC1
SCHEMBL2049260 0.74 HTR1A (0.44) SLC6A2SLC6A4SLC6A3KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7964531-B2 3-phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-21 US disclosed
US-20100041555-A1 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same MITSUI CHEMICALS AGRO, INC. (JP) 2010-02-18 US disclosed
US-7608563-B2 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same MITSUI AGRO CHEMICALS, INC. (JP) 2009-10-27 US disclosed
EP-1426365-B9 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME MITSUI CHEMICALS AGRO INC (JP) 2009-10-21 EP disclosed
EP-1426365-B1 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME SANKYO AGRO CO LTD (JP) 2009-07-15 EP disclosed
US-20050037925-A1 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same SANKYO AGRO COMPANY, LIMITED (JP) 2005-02-17 US disclosed
EP-1426365-A1 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME Sankyo Agro Company, Limited (JP) 2004-06-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041555-A1 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same CBR3, DDT, CBR1 SLC6A2 3620/4885SLC6A4 3104/4885SLC6A3 1443/4885
US-20050037925-A1 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same CBR3, DDT, CHRM2 SLC6A2 3617/4885SLC6A4 3163/4885SLC6A3 1647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.