Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.89 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL20486350 | 1.00 | SIGMAR1 (0.89) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Fumaric Acid SCHEMBL18585977 | 1.00 | SIGMAR1 (0.89) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9978379 | 0.94 | SIGMAR1 (1.00) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29949299 | 0.94 | SIGMAR1 (1.00) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL17848820 | 0.94 | SIGMAR1 (1.00) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Fumaric Acid SCHEMBL18586005 | 0.91 | SIGMAR1 (0.73) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Fumaric Acid SCHEMBL20485987 | 0.91 | SIGMAR1 (0.73) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Maleic Acid SCHEMBL20486027 | 0.91 | SIGMAR1 (0.73) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Fumaric Acid SCHEMBL20485988 | 0.91 | SIGMAR1 (0.73) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Maleic Acid SCHEMBL20486026 | 0.91 | SIGMAR1 (0.73) | SIGMAR1CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344620-B1 | 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1H-PYRAZOL-3-YL)METHOXY)ETHYL) PIPERAZIN-1-YL)ETHANONE SALTS | ESTEVE PHARMACEUTICALS SA (ES) | 2022-10-26 | — | — | EP | disclosed |
| US-10640468-B2 | 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-Yl)methoxy)ethyl)piperazin-1- Yl)ethanone salts | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-05-05 | — | — | US | disclosed |
| US-20180251430-A1 | 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1H-PYRAZOL-3-YL)METHOXY)ETHYL)PIPERAZIN-1-YL)ETHANONE SALTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2018-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640468-B2 | 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-Yl)methoxy)ethyl)piperazin-1- Yl)ethanone salts | SIGMAR1, OPRK1, TMEM97 | SIGMAR1 1/4885CYP1A2 101/4885CYP3A4 189/4885 |
| US-20180251430-A1 | 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1H-PYRAZOL-3-YL)METHOXY)ETHYL)PIPERAZIN-1-YL)ETHANONE SALTS | SIGMAR1, OPRK1, TMEM97 | SIGMAR1 1/4885CYP1A2 117/4885CYP3A4 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.