Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20487156 | 1.00 | TSHR (0.53) | TSHRHPGDLMNAMAPK1KMT2A | |
| Ammonia Solution, Strong SCHEMBL27753143 | 0.98 | TSHR (0.51) | TSHRHPGDLMNAMAPK1KMT2A | |
| SCHEMBL28902634 | 0.86 | HPGD (0.49) | HPGDLMNAMAPK1KMT2ACHRM1 | |
| SCHEMBL28353809 | 0.85 | LMNA (0.52) | HPGDLMNAMAPK1KMT2ACHRM1 | |
| SCHEMBL3454217 | 0.84 | LMNA (0.55) | HPGDLMNAMAPK1CHRM1CHRM3 | |
| SCHEMBL3454215 | 0.84 | LMNA (0.55) | HPGDLMNAMAPK1CHRM1CHRM3 | |
| SCHEMBL5072148 | 0.83 | ALDH1A1 (0.49) | TSHRLMNAMAPK1KMT2ACHRM1 | |
| SCHEMBL2420427 | 0.82 | TSHR (0.53) | TSHRHPGDLMNAKMT2ACHRM1 | |
| SCHEMBL28474895 | 0.82 | HCAR2 (0.51) | TSHRHPGDLMNAMAPK1CHRM1 | |
| SCHEMBL28474896 | 0.82 | HCAR2 (0.51) | TSHRHPGDLMNAMAPK1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4273132-A2 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | Gilead Sciences, Inc. (US) | 2023-11-08 | — | — | EP | disclosed |
| EP-3589636-B1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | GILEAD SCIENCES INC (US) | 2023-09-13 | — | — | EP | disclosed |
| US-20210024537-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | GILEAD SCIENCES, INC. | 2021-01-28 | — | — | US | disclosed |
| US-10745412-B2 | Processes for preparing ACC inhibitors and solid forms thereof | GILEAD SCIENCES, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200199147-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | GILEAD SCIENCES, INC. | 2020-06-25 | — | — | US | disclosed |
| US-20180298025-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | GILEAD SCIENCES, INC. | 2018-10-18 | — | — | US | disclosed |
| WO-2018161022-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | GILEAD SCIENCES, INC. (US) | 2018-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024537-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | ACACA, ACACB, ACAT2 | TSHR 4377/4885HPGD 1923/4885LMNA 2323/4885 |
| US-20180298025-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | ACACA, ACACB, ACAT2 | TSHR 4377/4885HPGD 1923/4885LMNA 2323/4885 |
| US-10745412-B2 | Processes for preparing ACC inhibitors and solid forms thereof | ACACA, ACACB, ACAT2 | TSHR 4377/4885HPGD 1923/4885LMNA 2323/4885 |
| US-20200199147-A1 | PROCESSES FOR PREPARING ACC INHIBITORS AND SOLID FORMS THEREOF | ACACA, ACACB, ACAT2 | TSHR 4377/4885HPGD 1923/4885LMNA 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.