Succinic Acid

Succinic Acid

SCHEMBL2048766

C[n+]1ccccc1.C[n+]1ccccc1.O=C([O-])CCC(=O)[O-]

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.41
HDAC3 O15379 3/20 0.40
HDAC1 Q13547 3/20 0.40
HDAC2 Q92769 3/20 0.40
HDAC8 Q9BY41 3/20 0.40
FFAR3 O14843 2/20 0.40
HDAC4 P56524 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
CA1 P00915 3/20 0.36
APOBEC3A P31941 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
APOBEC3G Q9HC16 1/20 0.33
SLC2A1 P11166 1/20 0.33
KMT2A Q03164 1/20 0.33
NNMT P40261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL2456076 0.86 USP2 (0.41) USP2HDAC3HDAC1HDAC2HDAC8
Bicarbonate SCHEMBL28802052 0.85 USP2 (0.46) USP2CA1APOBEC3ACTDSP1APOBEC3G
SCHEMBL17418702 0.84 SLC2A1 (0.35) USP2HDAC3HDAC1HDAC2HDAC8
Acetic Acid SCHEMBL2039260 0.82 USP2 (0.45) USP2FFAR3CA1APOBEC3ACTDSP1
Acetic Acid SCHEMBL7068267 0.82 USP2 (0.45) USP2FFAR3CA1APOBEC3ACTDSP1
Oxalic Acid SCHEMBL21814394 0.82 USP2 (0.45) USP2CA1APOBEC3ACTDSP1APOBEC3G
Acetic Acid SCHEMBL9159557 0.80 USP2 (0.43) USP2FFAR3CA1APOBEC3ACTDSP1
Acetic Acid SCHEMBL2048768 0.80 USP2 (0.43) USP2FFAR3CA1APOBEC3ACTDSP1
SCHEMBL17418205 0.80 TSHR (0.32) USP2
SCHEMBL17418212 0.80 ALDH1A1 (0.36) USP2HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110132646-A1 FLAME RETARDANT EPOXY RESIN COMPOSITION, PREPREG AND LAMINATE THEREOF ICL-IP AMERICA INC. (US) 2011-06-09 US disclosed
EP-0954553-B2 LATENT CATALYSTS FOR EPOXY CURING SYSTEMS DOW GLOBAL TECHNOLOGIES INC (US) 2008-12-10 EP disclosed
EP-0954553-B1 LATENT CATALYSTS FOR EPOXY CURING SYSTEMS DOW GLOBAL TECHNOLOGIES INC (US) 2004-08-11 EP disclosed
US-20040086720-A1 Latent catalysts for epoxy curing systems GAN JOSEPH (DE) 2004-05-06 US disclosed
US-6613839-B1 Polyepoxide, catalyst/cure inhibitor complex and anhydride THE DOW CHEMICAL COMPANY 2003-09-02 US disclosed