Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.58 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.58 |
| ▸ | CHRNA6 | Q15825 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26124277 | 0.93 | HPGD (0.68) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL3828585 | 0.91 | ALDH1A1 (0.78) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL19569940 | 0.89 | ALDH1A1 (0.75) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL2956853 | 0.89 | — | — | |
| SCHEMBL29746376 | 0.88 | CHRNB2 (0.81) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL2677613 | 0.87 | ALDH1A1 (0.72) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL2677292 | 0.86 | HPGD (0.59) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL2676701 | 0.85 | ALDH1A1 (0.76) | ALDH1A1HPGDTSHRHTTHSD11B1 | |
| SCHEMBL21409274 | 0.85 | CHRNB2 (0.64) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 | |
| SCHEMBL3595898 | 0.85 | TSHR (0.52) | ALDH1A1HPGDTSHRCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073133-A1 | PYRIDAZIN-3(2H)-ONE AND PYRIDIN-2(1H)-ONE PARP INHIBITOR COMPOUNDS | AZKARRA THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| US-20240083908-A1 | TETRAHYDROTHIENOPYRIMIDINESULFONAMIDE COMPOUNDS | ALIVEXIS, INC. (JP) | 2024-03-14 | — | — | US | disclosed |
| EP-4269415-A1 | TETRAHYDRO THIENOPYRIDINE SULFONAMIDE COMPOUND | Modulus Discovery, Inc. (JP) | 2023-11-01 | — | — | EP | disclosed |
| US-11364241-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210069191-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2021-03-11 | — | — | US | disclosed |
| US-10780088-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200261454-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2020-08-20 | — | — | US | disclosed |
| US-10543209-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180117045-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | MEDIVATION TECHNOLOGIES LLC | 2018-05-03 | — | — | US | disclosed |
| US-9820985-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | MEDIVATION TECHNOLOGIES LLC (US) | 2017-11-21 | — | — | US | disclosed |
| EP-1752449-A1 | Pharmaceutical coposition | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-7119092-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| US-7060702-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050137208-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2005-06-23 | — | — | US | disclosed |
| EP-1524266-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2005-04-20 | — | — | EP | disclosed |
| EP-1326832-B1 | CHEMICAL COMPOUNDS | GLAXO GROUP LTD (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040014770-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | US | disclosed |
| EP-1326832-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032867-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180117045-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
| US-20240083908-A1 | TETRAHYDROTHIENOPYRIMIDINESULFONAMIDE COMPOUNDS | TYMS, TYMP, TPMT | ALDH1A1 2342/4885HPGD 512/4885TSHR 2507/4885 |
| US-10780088-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
| US-11364241-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
| US-20050137208-A1 | Chemical compounds | TACR2, TAC3, MC2R | ALDH1A1 3334/4885HPGD 2610/4885TSHR 449/4885 |
| US-10543209-B2 | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
| US-20040014770-A1 | Chemical compounds | HCK, KCNK4, GRK4 | ALDH1A1 2296/4885HPGD 3783/4885TSHR 1186/4885 |
| US-20060142302-A1 | Chemical compounds | TACR2, TAC3, MC2R | ALDH1A1 3334/4885HPGD 2610/4885TSHR 449/4885 |
| US-20200261454-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
| US-20210069191-A1 | DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | PARP1, PARP2, PARP11 | ALDH1A1 326/4885HPGD 242/4885TSHR 3935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.