Sugi Predict

Sugi Predict / Compounds / SCHEMBL20500970

SCHEMBL20500970

SCHEMBL20500970

Nc1ncc(-c2cccc(NC(=O)Nc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c2)[nH]1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 7/20 0.57
▸ TEK Q02763 2/20 0.54
▸ RAF1 P04049 2/20 0.53
▸ SCN4A P35499 1/20 0.52
▸ SCN9A Q15858 1/20 0.52
▸ SCN3A Q9NY46 1/20 0.52
▸ MAPT P10636 2/20 0.49
▸ TP53 P04637 1/20 0.49
▸ RIPK1 Q13546 1/20 0.48
▸ EGFR P00533 1/20 0.48
▸ FGFR1 P11362 1/20 0.48
▸ MEN1 O00255 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ RAB9A P51151 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ LCK P06239 1/20 0.48
▸ CDK8 P49336 3/20 0.47
▸ CDK7 P50613 1/20 0.47
▸ CDK6 Q00534 1/20 0.47
▸ ALDH1A1 P00352 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20500937 0.94 KDR (0.57) KDRTEKRAF1SCN4ASCN9A
SCHEMBL20501010 0.91 BAZ1A (0.54) KDRSCN4ASCN9ASCN3AMAPT
SCHEMBL20500958 0.89 SCN4A (0.48) KDRTEKRAF1SCN4ASCN9A
SCHEMBL20501030 0.88 SCN9A (0.61) KDRSCN4ASCN9ASCN3AMAPT
SCHEMBL20500966 0.86 SCN9A (0.51) KDRRAF1SCN4ASCN9ASCN3A
SCHEMBL20501106 0.85 SCN9A (0.50) KDRSCN4ASCN9ASCN3AMAPT
SCHEMBL20501076 0.85 SCN9A (0.61) KDRSCN4ASCN9ASCN3AMAPT
SCHEMBL20500967 0.84 SCN9A (0.53) KDRTEKSCN4ASCN9ASCN3A
SCHEMBL20501016 0.84 SCN9A (0.55) KDRSCN4ASCN9ASCN3AMAPT
SCHEMBL20501157 0.83 SCN9A (0.57) KDRSCN4ASCN9ASCN3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth NORTH CAROLINA STATE UNIVERSITY (US) 2023-02-21 — — US disclosed
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-01-06 — — US disclosed
CN-110740645-A 2-aminoimidazole-phenyl derivatives for controlling microbial growth 北卡罗莱纳州立大学 2020-01-31 — — CN disclosed
WO-2018169752-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH NORTH CAROLINA STATE UNIVERSITY (US) 2018-09-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11582970-B2 2-aminoimidazole-phenyl derivatives useful for controlling microbial growth DDC, IL4I1, ING2 KDR 2600/4885TEK 1782/4885RAF1 1638/4885
US-20220000118-A1 2-AMINOIMIDAZOLE-PHENYL DERIVATIVES USEFUL FOR CONTROLLING MICROBIAL GROWTH DDC, IL4I1, ING2 KDR 2600/4885TEK 1782/4885RAF1 1638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.