SCHEMBL2050196

SCHEMBL2050196

c1ccc(C[Si](Cc2ccccc2)(Cc2ccccc2)ON=C(CC(=NO[Si](Cc2ccccc2)(Cc2ccccc2)Cc2ccccc2)c2ccccc2)CC(=NO[Si](Cc2ccccc2)(Cc2ccccc2)Cc2ccccc2)c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.39
GRIN1 Q05586 2/20 0.34
GRIN2B Q13224 2/20 0.34
ATM Q13315 1/20 0.33
KMT2A Q03164 5/20 0.33
TDP1 Q9NUW8 3/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
GAA P10253 3/20 0.33
MAPT P10636 2/20 0.33
SMN1; SMN2 Q16637 3/20 0.32
MAPK1 P28482 2/20 0.32
VNN1 O95497 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
ALDH1A1 P00352 4/20 0.32
LMNA P02545 3/20 0.32
KDM4E B2RXH2 2/20 0.32
HPGD P15428 1/20 0.31
HTT P42858 2/20 0.31
SLC6A2 P23975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2050192 1.00 CTSL (0.39) CTSLGRIN1GRIN2BATMKMT2A
SCHEMBL2045431 0.79 ALDH1A1 (0.35) KMT2AL3MBTL1GAAMAPTSMN1; SMN2
SCHEMBL2045429 0.79 ALDH1A1 (0.35) KMT2AL3MBTL1GAAMAPTSMN1; SMN2
SCHEMBL2045904 0.79 ATM (0.40) CTSLATMKMT2ATDP1L3MBTL1
SCHEMBL2045908 0.79 ATM (0.40) CTSLATMKMT2ATDP1L3MBTL1
SCHEMBL214457 0.76 LMNA (0.53) GRIN1GRIN2BATMTDP1L3MBTL1
SCHEMBL214062 0.73 NOS2 (0.40) TDP1L3MBTL1GAAMAPTSMN1; SMN2
SCHEMBL2049290 0.72 NPC1 (0.43) CTSLATMKMT2ATDP1L3MBTL1
SCHEMBL2049293 0.72 NPC1 (0.43) CTSLATMKMT2ATDP1L3MBTL1
SCHEMBL2050491 0.72 ATM (0.44) ATMKMT2AL3MBTL1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP claimed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US claimed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP claimed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US claimed
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP disclosed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US disclosed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP disclosed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US disclosed