Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26092935 | 0.84 | ALDH1A1 (0.45) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL24673913 | 0.79 | USP2 (0.51) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL10253506 | 0.79 | USP2 (0.51) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL30897992 | 0.78 | USP2 (0.50) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL513246 | 0.78 | USP2 (0.50) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL3719620 | 0.76 | USP2 (0.49) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL843458 | 0.76 | USP2 (0.49) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL1689676 | 0.76 | USP2 (0.49) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 | |
| SCHEMBL2948300 | 0.76 | USP2 (0.49) | MAPTUSP2SMN1; SMN2GRM5ESR2 | |
| SCHEMBL14419067 | 0.76 | USP2 (0.49) | MAPTALDH1A1LMNAUSP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752628-B2 | Compounds and methods for treating synovial sarcomas | THE BROAD INSTITUTE, INC. (US) | 2020-08-25 | — | — | US | disclosed |
| WO-2018213422-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS (US) | 2018-11-22 | — | — | WO | disclosed |
| US-20180327407-A1 | COMPOUNDS AND METHODS FOR TREATING SYNOVIAL SARCOMAS | HOWARD HUGHES MEDICAL INSTITUTE | 2018-11-15 | — | — | US | disclosed |
| WO-2018187614-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS (US) | 2018-10-11 | — | — | WO | disclosed |
| EP-3377499-A1 | COMPOUNDS AND METHODS FOR TREATING SYNOVIAL SARCOMAS | Kadoch, Cigall (US) | 2018-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180327407-A1 | COMPOUNDS AND METHODS FOR TREATING SYNOVIAL SARCOMAS | EWSR1, TP53, PAX3 | MAPT 4571/4885ALDH1A1 118/4885LMNA 1341/4885 |
| US-10752628-B2 | Compounds and methods for treating synovial sarcomas | EWSR1, TP53, PAX3 | MAPT 4571/4885ALDH1A1 118/4885LMNA 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.