Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPER1 | Q99527 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | GPR183 | P32249 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 2/20 | 0.63 |
| ▸ | MASP2 | O00187 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | ALPL | P05186 | 1/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21105585 | 1.00 | GPER1 (0.71) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL14129132 | 0.87 | L3MBTL1 (0.72) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL915769 | 0.86 | L3MBTL1 (0.71) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL14582287 | 0.85 | KMT2A (0.80) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL21105592 | 0.84 | L3MBTL1 (0.71) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL18130996 | 0.84 | L3MBTL1 (0.71) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL12700983 | 0.83 | GPER1 (1.00) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL12700948 | 0.83 | GPER1 (1.00) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL21106239 | 0.83 | GPER1 (0.89) | GPER1L3MBTL1GPR183NPC1RAB9A | |
| SCHEMBL12700921 | 0.83 | GPER1 (1.00) | GPER1L3MBTL1GPR183NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11369618-B2 | Compounds, compositions and methods for prevention and/or treatment of cancer | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200306261-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTION AND/OR TREATMENT OF CANCER | UNIV PENNSYLVANIA (US) | 2020-10-01 | — | — | US | disclosed |
| WO-2019118855-A1 | COMPOUNDS AND COMPOSITIONS FOR PREVENTION AND/OR TREATMENT OF CANCER | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2019-06-20 | — | — | WO | disclosed |
| US-20180273482-A1 | COMPOSITIONS AND METHODS FOR INCREASING, OR PREVENTING OR REVERSING LOSS OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200306261-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTION AND/OR TREATMENT OF CANCER | GPER1, GPR3, GPR4 | GPER1 1/4885L3MBTL1 4152/4885GPR183 9/4885 |
| US-20180273482-A1 | COMPOSITIONS AND METHODS FOR INCREASING, OR PREVENTING OR REVERSING LOSS OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | GPER1, SHBG, ESRRB | GPER1 1/4885L3MBTL1 3404/4885GPR183 242/4885 |
| US-11369618-B2 | Compounds, compositions and methods for prevention and/or treatment of cancer | GPER1, GPR3, GPR4 | GPER1 1/4885L3MBTL1 4152/4885GPR183 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.