SCHEMBL2050836

SCHEMBL2050836

c1ccc(C(CCC(=NO[Si](c2ccccc2)(c2ccccc2)c2ccccc2)c2ccccc2)=NO[Si](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 8/20 0.40
ATM Q13315 1/20 0.38
PPARG P37231 7/20 0.36
GAA P10253 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35
DRD4 P21917 6/20 0.35
DRD2 P14416 2/20 0.35
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2050834 1.00 PPARA (0.40) PPARAATMPPARGGAAL3MBTL1
SCHEMBL2046809 0.93 PPARA (0.38) PPARAATMPPARGGAAL3MBTL1
SCHEMBL2046807 0.93 PPARA (0.38) PPARAATMPPARGGAAL3MBTL1
SCHEMBL9898980 0.91 NR4A2 (0.47) PPARAPPARGGAAL3MBTL1LMNA
SCHEMBL2047973 0.91 PPARA (0.41) PPARAATMPPARGL3MBTL1LMNA
SCHEMBL9898979 0.91 NR4A2 (0.47) PPARAPPARGGAAL3MBTL1LMNA
SCHEMBL2047974 0.91 PPARA (0.41) PPARAATMPPARGL3MBTL1LMNA
SCHEMBL9898977 0.85 L3MBTL1 (0.49) PPARAGAAL3MBTL1LMNAMAPT
SCHEMBL9898975 0.85 L3MBTL1 (0.49) PPARAGAAL3MBTL1LMNAMAPT
SCHEMBL2050607 0.83 PPARA (0.44) PPARAATMPPARGGAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP claimed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US claimed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP claimed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US claimed
EP-2516475-B1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORP (JP) 2020-10-07 EP disclosed
US-8338544-B2 Polymers functionalized with polyoxime compounds and methods for their manufacture BRIDGESTONE CORPORATION (JP) 2012-12-25 US disclosed
EP-2516475-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE Bridgestone Corporation (JP) 2012-10-31 EP disclosed
US-20110152449-A1 POLYMERS FUNCTIONALIZED WITH POLYOXIME COMPOUNDS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-06-23 US disclosed