Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.36 |
| ▸ | MGMT | P16455 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL20510391 | 0.95 | LGALS8 (0.39) | LGALS8MAOBSLC6A2SYNJ2MGMT | |
| SCHEMBL20510248 | 0.84 | IGF2R (0.41) | LGALS8MAOB | |
| SCHEMBL26349835 | 0.84 | MAOB (0.39) | LGALS8MAOBSLC6A2SLC5A1SLC5A2 | |
| SCHEMBL20510818 | 0.80 | MDK (0.35) | MAOB | |
| Water SCHEMBL20510246 | 0.80 | IGF2R (0.41) | MAOB | |
| SCHEMBL22750109 | 0.79 | LGALS8 (0.46) | LGALS8MAOBSYNJ2MGMTKDM4E | |
| SCHEMBL25243911 | 0.78 | MMP13 (0.44) | LGALS8MAOBSYNJ2MGMTKDM4E | |
| SCHEMBL29454860 | 0.78 | MMP13 (0.44) | LGALS8MAOBSYNJ2MGMTKDM4E | |
| SCHEMBL28333071 | 0.78 | LMNA (0.54) | LGALS8MAOBSYNJ2MGMTKDM4E | |
| SCHEMBL30891325 | 0.77 | HTT (0.46) | LGALS8MAOBMGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600381-A1 | GLUCOSE RESPONSIVE INSULIN COMPRISING A TRI-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | Merck Sharp & Dohme Corp. (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018175272-A1 | GLUCOSE RESPONSIVE INSULIN COMPRISING A TRI-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES | MERCK SHARP & DOHME CORP. (US) | 2018-09-27 | — | — | WO | disclosed |